Anti-Alzheimer, Antiglaucoma, and Antidiabetic Activities of Sainfoin (<i>Onobrychis buhseana</i> Boiss.)

Jafarova S., Aydin T., Isayev J., Saglamtas R., Özgökçe F., KAZAZ C., ...Daha Fazla

CHEMISTRY & BIODIVERSITY, cilt.22, sa.7, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 7
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1002/cbdv.202402013
  • Dergi Adı: CHEMISTRY & BIODIVERSITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core, EMBASE, MEDLINE
  • Anahtar Kelimeler: buhseanol, enzyme inhibition, Onobrychis buhseana Boiss, sainfoin, β-arbutin
  • Atatürk Üniversitesi Adresli: Evet

Özet

Onobrychis Adans. species, known as 'sainfoin,' are commercially valuable plants cultivated to produce high-protein animal feed. In this study, the ethanol extract of Onobrychis buhseana Boiss., which is widely distributed in Azerbaijan, was subjected to silica gel column and thin-layer chromatography for the first time, leading to the isolation of a new natural hydroquinone oligomer, named buhseanol (1), along with two known compounds, beta-arbutin (2) and an inositol derivative (3). The chemical structure of buhseanol (1) was characterized by proton nuclear magnetic resonance (1H-NMR), carbon-13 NMR, Attached Proton Test NMR, and liquid chromatography-tandem mass spectrometry. Buhseanol (1), beta-arbutin (2), and the ethanol extract were evaluated for their anti-Alzheimer's, anti-glaucoma, and anti-diabetic effects, with both the extract and buhseanol (1) potentially showing these activities. The inositol derivative (3) did not exhibit any of these activities.