The Role of the Nonspecific Inflammatory Markers in Determining the Anatomic Extent of Venous Thromboembolism
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, cilt.21, sa.2, ss.181-185, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 21 Sayı: 2
- Basım Tarihi: 2015
- Doi Numarası: 10.1177/1076029613494469
- Dergi Adı: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.181-185
- Anahtar Kelimeler: deep venous thrombosis, thrombosis, pulmonary embolism, C-REACTIVE PROTEIN, DEEP-VEIN THROMBOSIS, LYMPHOCYTE RATIO, ACUTE-PHASE, RISK, ASSOCIATION, PREVENTION, NEUTROPHIL, ACTIVATION, DISEASE
- Atatürk Üniversitesi Adresli: Evet
Özet
We aimed to investigate the relationship between the extent of venous thromboembolism (VTE) and nonspecific inflammatory markers such as neutrophil to lymphocyte ratio (NLR) and high-sensitivity C-reactive protein (hs-CRP). We retrospectively enrolled 77 patients with VTE (distal deep vein thrombosis [DVT], n = 19; proximal DVT, n = 32; and pulmonary thromboembolism [PTE], n = 26) and 34 healthy controls. In the performed analysis of variance, the levels of white blood cell, NLR, and hs-CRP were clearly different among the groups (control, distal and proximal DVT, and PTE) (P <.001). Especially, a significant increase from the control group to the DVT and PTE was observed in the analysis made for NLR. In the performed receiver-operating characteristic curve analysis, area under curve (AUC) = 0.849 and P <.001 were detected for NLR > 1.84. For this value, the sensitivity and specificity were determined as 88.2% and 67.6%, respectively. The NLR is an inexpensive and a readily available marker that may be effective in determining the extent of VTE, and it is useful for risk stratification in patients with VTE.