Healthcare-associated Crimean-Congo haemorrhagic fever in Turkey, 2002-2014: a multicentre retrospective cross-sectional study

LEBLEBİCİOĞLU O. H., SÜNBÜL M., GÜNER H. R., BODUR H., BULUT C., DUYGU F., ...Daha Fazla

CLINICAL MICROBIOLOGY AND INFECTION, cilt.22, sa.4, 2016 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.cmi.2015.11.024
  • Dergi Adı: CLINICAL MICROBIOLOGY AND INFECTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Crimean-Congo haemorrhagic fever, healthcare associated, infection prevention and control, ribavirin, viral haemorrhagic fever, NOSOCOMIAL TRANSMISSION, RIBAVIRIN, PROPHYLAXIS, VIRUS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Healthcare-related transmission of Crimean-Congo haemorrhagic fever (CCHF) is a well-recognized hazard. We report a multicentre retrospective cross-sectional study undertaken in Turkey in 2014 in nine hospitals, regional reference centres for CCHF, covering the years 2002 to 2014 inclusive. Data were systematically extracted from charts of all personnel with a reported health care injury/accident related to CCHF. Blood samples were tested for CCHF IgM/IgG by enzyme-linked immunosorbent assay and/or viral nucleic acid detection by PCR after the injury. Fifty-one healthcare-related exposures were identified. Twenty-five (49%) of 51 resulted in laboratory-confirmed infection, with a 16% (4/25) overall mortality. The main route of exposure was needlestick injury in 32/51 (62.7%). A potential benefit of post-exposure prophylaxis with ribavirin was identified. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.