Advances of functional nucleic acids based on specific recognition:A review

Liu, Beibei; Chen, Ge; El-Aty, ABDELATY; Zhai, Rongqi; Liu, Guangyang; Xu, Xiaomin; Zhang, Yanguo; Li, Lingyun; Zhang, Jie; Xu, Donghui

doi:10.1016/j.ijbiomac.2025.140828

Advances of functional nucleic acids based on specific recognition:A review

Liu B., Chen G., El-Aty A. M. A., Zhai R., Liu G., Xu X., ...Daha Fazla

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, cilt.304, 2025 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Derleme
Cilt numarası: 304
Basım Tarihi: 2025
Doi Numarası: 10.1016/j.ijbiomac.2025.140828
Dergi Adı: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, Compendex, EMBASE, INSPEC, MEDLINE
Atatürk Üniversitesi Adresli: Evet

Özet

Nucleic acids, which are fundamental to living organisms, play a crucial role in carrying and transmitting genetic information. Advances in molecular biology have led to the exploration of functional nucleic acids (FNAs), including aptamers, DNAzymes, and G-quadruplexes, known for specific recognition or catalysis. FNAs with high specificity, sequence programmability, modification ease and biocompatibility, have extensive applications in biosensing, environmental monitoring, drug delivery and cancer diagnosis. This review focuses on the structure and specific recognition principles of FNAs, followed by an exploration for biosensing and biomedical applications, offering insights into current challenges and future trends in FNAs as recognition elements.