Changes of PSA concentrations in serum and saliva of healthy women during the menstrual cycle

Aksoy H., Akcay F., Umudum Z., Yildirim A., Memisogullari R.

ANNALS OF CLINICAL AND LABORATORY SCIENCE, cilt.32, sa.1, ss.31-36, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 1
  • Basım Tarihi: 2002
  • Dergi Adı: ANNALS OF CLINICAL AND LABORATORY SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.31-36
  • Anahtar Kelimeler: prostate specific antigen (PSA), saliva, menstrual cycle, PROSTATE-SPECIFIC ANTIGEN, AMNIOTIC-FLUID, BREAST TISSUES, IMMUNOREACTIVITY, FEMALE, TUMORS, GLAND, LOCALIZATION, EXPRESSION, MARKER
  • Atatürk Üniversitesi Adresli: Evet

Özet

This study investigated the changes of prostate specific antigen (PSA) concentrations in serum and saliva of women during the menstrual cycle. Thirty healthy volunteers (age 23-35 yr) were enrolled in the study. During the menstrual cycle, serum and saliva PSA concentrations on days 9 (follicular phase) and 14 (mid-cycle) were significantly higher than on days 4 (early follicular phase) and 21 (luteal phase). The expected changes in gonadal hormones were seen, as evidenced by significantly higher serum estradiol and progesterone concentrations during the midcycle and luteal phase, compared to the other phases of the cycle. Serum PSA concentrations were positively correlated with salivary PSA concentrations at all 4 times (days 4, 9, 14, and 2 1) of the menstrual cycle, but not with the serum progesterone or estrogen concentrations. This study suggests that salivary PSA, rather than being produced in the salivary gland, may reflect the serum PSA during the normal menstrual cycle.