Synthesis and Investigation of Anticancer Properties Fluoro Substitued BisChalcone Derivatives

Anıl D., Özcan Ş., Göbek A., Cantürk Z., Burmaoğlu S., Algül Ö.

8. International Drug Chemistry Conference, Antalya, Türkiye, 27 Şubat - 01 Mart 2020, ss.197-200

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Basıldığı Şehir: Antalya
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.197-200
  • Atatürk Üniversitesi Adresli: Evet

Özet

The Claisen-Schmidt condensation reaction was used for the synthesis of bis-chalcone derivatives. Reaction of ketone derivatives 2 and 11 with related aldehydes, bis-chalcone derivatives were obtained. It is known that fluoro atom has positive effects on anticancer activity, for this purpose especially fluoro substitued benzaldehyde derivatives was used. Four new fluoro substituted bis-chalcone derivatives were synthesized and their anticancer activity was determined against human colorectal adenocarcinoma cells (Caco-2), human breast cancer cells (MDA-MB231), rattus pheochromocytoma (PC12) and mouse healthy fibroblast cells (NIH3T3) and IC50 concentrations of the compounds, and cell viability was determined by MTT assay.