The anti-genotoxic effect of some lichenic acids
JOURNAL OF THE NATIONAL SCIENCE FOUNDATION OF SRI LANKA, cilt.46, sa.2, ss.227-231, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 2
- Basım Tarihi: 2018
- Doi Numarası: 10.4038/jnsfsr.v46i2.8423
- Dergi Adı: JOURNAL OF THE NATIONAL SCIENCE FOUNDATION OF SRI LANKA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.227-231
- Anahtar Kelimeler: Comet assay, diffractaic acid, lecanoric acid, lichen compounds, lobaric acid, vulpinic acid
- Atatürk Üniversitesi Adresli: Evet
Özet
Four lichen secondary metabolites; diffractaic acid, lecanoric acid, lobaric acid and vulpinic acid were evaluated for the anti-genotoxic effects on human lymphocytes in vitro using single cell gel electrophoresis (SCGE) or comet assay. Carbon tetrachloride, a known mutagenic agent was used as the positive control in the comet test system. The results revealed that at all concentrations, the tested compounds mediated a significant decrease in total DNA damage (comet assay) as compared with positive controls (p > 0.05). The most effective doses of lichen acids were found to be 100 mu gmL(-1) of diffractic acid, lobaric acid and vulpinic acid, and 50 mu gmL(-1) of lecanoric acid. In addition, it was determined that the most effective among the tested compounds was vulpinic acid.