Production of (R)-3 '-fluorophenylethan-1-ol by Trichothecium roseum isolate in a laboratory scale bioreactor

KURBANOĞLU E. B., TAŞKIN M., Zilbeyaz K., Kurbanoglu N. I.

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, cilt.84, sa.10, ss.1474-1479, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 84 Sayı: 10
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/jctb.2204
  • Dergi Adı: JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1474-1479
  • Atatürk Üniversitesi Adresli: Evet

Özet

BACKGROUND: Enantiomerically pure, fluorinated compounds play an important role in medicinal chemistry. Trichothecium roseum strains were isolated for the production of (R)-3'-fluorophenylethan-1-ol. Biocatalytic production of optically active (R)3'-fluorophenylethan-1-ol was achieved by asymmetric reduction of 3'-fluoroacetophenone in a batch culture of Trichothecium roseum using ram horn peptone (RHP). The reaction conditions (pH, temperature and agitation) required to improve the conversion of 3'-fluoroacetophenone and enantiomeric excess (ee) of (R)-3'-fluorophenylethan-1-ol were studied.