Human leukocyte antigen (HLA) class I and II alleles in Turkish patients with rheumatic heart disease

GÜNDOĞDU F., İSLAMOĞLU Y., PİRİM İ., GÜRLERTOP H. Y., DOĞAN H., ARSLAN Ş., ...Daha Fazla

JOURNAL OF HEART VALVE DISEASE, cilt.16, sa.3, ss.293-299, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 3
  • Basım Tarihi: 2007
  • Dergi Adı: JOURNAL OF HEART VALVE DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.293-299
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background and aim of the study: Rheumatic heart disease (RHD) is often preceded by rheumatic fever (RF). The disease is a multisystem inflammatory condition that develops as a sequel to untreated throat infection by group A beta-hemolytic streptococci. Several studies have suggested that genetic susceptibility to RHD may be linked to human leukocyte antigen (HLA) class II alleles. The study aim was to investigate the association between RHD and the antigens HLA-A, -B, -C, -DR and -DQ profile in RHD patients in eastern Turkey.