Expression of hCA IX isoenzyme by using sumo fusion partner and examining the effects of antitumor drugs

Yerlikaya E., ERDOĞAN O., Demirdag R., Senturk M., KÜFREVİOĞLU Ö. İ.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.40, sa.4, ss.334-342, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1515/tjb-2015-0021
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.334-342
  • Anahtar Kelimeler: Cloning, expression, cancer, carbonic anhydrase IX, inhibition, CARBONIC-ANHYDRASE-IX, PROTEIN, HYPOXIA, TUMOR, PURIFICATION, BINDING, CANCER, MARKER, GENE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: In this study, investigating the effects of inhibition of the enzyme activity of some antitumor drugs and the Cancer-Related Human Carbonic Anhydrase IX (hCA IX) isoenzyme expressing as a SUMO fusion protein in an Escherichia coli expression system were aimed.