Akademik Veri Yönetim Sistemi
Food Bioscience, cilt.71, 2025 (SCI-Expanded, Scopus)
Cuminum cyminum L. (cumin) is widely used in traditional medicine and culinary practices, recognized for its antioxidant, anti-inflammatory, and antimicrobial properties. Cuminaldehyde, its primary bioactive compound, has shown promise in modulating oxidative stress and inflammation. However, its therapeutic potential in inflammatory bowel disease (IBD) remains unclear. This study aimed to evaluate the effects of cuminaldehyde on acetic acid-induced colitis in male Sprague Dawley rats (n = 36). Colitis was induced, and rats were subsequently treated with cuminaldehyde at doses of 50, 100, and 200 mg/kg, or sulfasalazine (500 mg/kg) as a reference, administered via drinking water for seven days. Parameters assessed included water consumption, body weight, biochemical and hematological markers, as well as macroscopic, histological, and genomic changes in colonic tissue. Cuminaldehyde treatment, particularly at a dose of 200 mg/kg, significantly reduced oxidative stress and inflammation in experimental colitis. Both macroscopic and microscopic evaluations demonstrated notable improvement in colonic damage in cuminaldehyde-treated groups. Hematological and biochemical parameters indicated attenuation of inflammation and tissue injury. The treated groups exhibited comparable or superior regeneration compared to the sulfasalazine group. These findings suggest that cuminaldehyde may represent a potential alternative therapeutic agent for colitis.