Inflammatory parameters in NSCLC with driver mutation

Buyukbayram M. E., Hannarici Z., Yılmaz A., TURHAN A., ÇAĞLAR A. A., ÇOBAN EŞDUR P., ...Daha Fazla

LUNG CANCER MANAGEMENT, cilt.13, sa.1, 2024 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 1
  • Basım Tarihi: 2024
  • Doi Numarası: 10.2217/lmt-2023-0014
  • Dergi Adı: LUNG CANCER MANAGEMENT
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Atatürk Üniversitesi Adresli: Evet

Özet

Aim: The tumor microenvironment of NSCLC with driver mutations, such as EGFR, ALK and ROS, is less inflammatory. Materials & methods: This retrospective study included 38 patients with NSCLC driver mutations. The relationship between clinical and inflammatory markers concerning progression-free survival and overall survival was analyzed based on Kaplan-Meier curves. Results: The mean age of the patients was 59.8 +/- 11.9. Progression-free survival and overall survival were significantly longer in patients under 65 years of age and with low neutrophil-lymphocyte ratio, low systemic immune-inflammation index and high lymphocyte count (p < 0.05). Conclusion: Unlike tumor biology, peripheral inflammatory parameters, such as neutrophil-lymphocyte ratio, systemic immune-inflammation index and lymphocyte count may be associated with survival in NSCLC patients with driver mutations.