Epigallocatechin-3-Gallate Provides Hepatoprotection Through Endoplasmic Reticulum Stress/TXNIP/NLRP3 Axis in Paracetamol-Induced Acute Liver Injury

DEMİRTAŞ N., Mazlumoglu B. S., Celep N. A., ÇADIRCI E., HALICI Z., Yücelik Ş. S.

Basic and Clinical Pharmacology and Toxicology, cilt.138, sa.1, 2026 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 138 Sayı: 1
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1111/bcpt.70155
  • Dergi Adı: Basic and Clinical Pharmacology and Toxicology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, Chimica, EMBASE, Environment Index, MEDLINE
  • Anahtar Kelimeler: (–)-epigallocatechin-3-gallate (EGCG), endoplasmic reticulum stress, inflammasome, liver, paracetamol
  • Atatürk Üniversitesi Adresli: Evet

Özet

Epigallocatechin-3-gallate (EGCG) is a polyphenolic compound with strong antioxidant properties and is abundantly found in green tea. We investigated how EGCG affects the liver injury of high-dose paracetamol in this study. In our study, 56 rats were divided into seven groups (n = 8): healthy control, EGCG (100 mg/kg), paracetamol (2 g/kg), paracetamol + EGCG 25 (2 g/kg + 25 mg/kg), paracetamol + EGCG 50 (2 g/kg + 50 mg/kg), paracetamol + EGCG 100 (2 g/kg + 100 mg/kg) and paracetamol + N-acetyl cysteine (NAC, 2 g/kg + 140 mg/kg). Our findings suggest that high-dose paracetamol induces liver injury through endoplasmic reticulum (ER) stress and that EGCG alleviates liver injury by attenuating ER stress-induced inflammasome signalling.