Vitamin B12, folic acid, vitamin D, iron, ferritin, magnesium, and HbA1c levels in patients with diabetes mellitus and dental prosthesis.


Ciftel S., Bilen A., Yanıkoglu N., Mercantepe F., Dayanan R., Ciftel E., ...Daha Fazla

European review for medical and pharmacological sciences, cilt.26, sa.19, ss.7135-7144, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 19
  • Basım Tarihi: 2022
  • Doi Numarası: 10.26355/eurrev_202210_29899
  • Dergi Adı: European review for medical and pharmacological sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.7135-7144
  • Anahtar Kelimeler: Diabetes, Vitamin B12, Magnesium, HbA1c, Dental prosthesis, NUTRITIONAL-STATUS, DIETARY QUALITY, SERUM FERRITIN, OLDER-ADULTS, IMPACT
  • Atatürk Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Diabetic patients may have vitamin deficiencies, which are import-ant in the follow-up and complications of diabe-tes for various reasons. It may be beneficial to in-clude the use of dental prosthesis among the pa-rameters that should be investigated as a cause of vitamin deficiency during the management and follow-up of diabetes mellitus. We aimed to inves-tigate the association between serum vitamin B12, folic acid, 25-hydroxyvitamin D, ferritin, iron, mag-nesium, and HbA1c levels in diabetic patients with and without removable dental prosthesis and in non-diabetic patients with prosthesis.PATIENTS AND METHODS: This study is a single-center case-control study. Participants were classified into the following groups: 1) Dia-betic patients (n = 528) with prosthesis, 2) non -di-abetic patients with prosthesis (n = 121) and 3) diabetic patients without prosthesis (n = 100). Vitamin B12, 25-hydroxyvitamin D, folic acid, fer-ritin, iron, magnesium, and HbA1c levels were measured and compared across the groups.RESULTS: A significant difference was ob-served between the groups with respect to the above parameters. Vitamin B12 levels were de-termined to be higher in the diabetic group with-out prosthesis. 25-hydroxyvitamin D levels were found to be significantly higher in the non -diabet-ic group with a prosthesis than in the other two groups. There was no statistical difference in the iron levels between the groups. Ferritin levels were observed to be significantly higher in the dia-betic group with prosthesis compared to the other two groups. Magnesium levels were significantly different between all the three groups. The highest magnesium levels were found in the non-diabetic group with prosthesis. HbA1c levels were found to be higher in the diabetic group with prosthesis. Magnesium levels were correlated with 25-hy-droxyvitamin D levels, but a negative correlation was observed between these and HbA1c.CONCLUSIONS: Serum vitamin B12 levels were lower in the diabetic and non-diabetic groups with prosthesis compared to the diabetic group without prosthesis. 25-hydroxyvitamin D levels were lower and ferritin was higher in the diabetic groups with and without prosthesis. Magnesium levels were significantly lower in the diabetic group with a prosthesis than in the other two groups. The mean HbA1c level was higher in the diabetic group with prosthesis. The comparison of diabetic patients receiving met-formin revealed a higher pronounced vitamin B12 deficiency in the diabetic group with pros-thesis. These findings show that those diabetic patients with prosthesis should be evaluated for vitamin B12, 25-hydroxyvitamin D, and magne-sium deficiency.