The antioxidant and genotoxic activities of Na2B4O7.10H2O in vitro

Çelikezen F. Ç., TÜRKEZ H., Aydin E.

Fresenius Environmental Bulletin, cilt.24, sa.3A, ss.947-953, 2015 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3A
  • Basım Tarihi: 2015
  • Dergi Adı: Fresenius Environmental Bulletin
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.947-953
  • Anahtar Kelimeler: Genotoxicity, Human blood cells, Micro-nucleus, Sister chromatid exchange, Sodium borate
  • Atatürk Üniversitesi Adresli: Evet

Özet

© by PSP.Boron is known as a trace element for animals and humans. Sodium borates are used in some cosmetics, detergents, and chemicals of photography, adhesives and textile compounds. It was aimed to evaluate the antioxidant potentials and genotoxic risk of sodium borate (Na2B4O7.10H2O) on human whole blood cultures in the extent of this study (w=5). Na2B4O7.10H2O was administrated at wide range concentrations (0-1280 μg/ml) to cultured human whole blood samples. The sister chromatid exchange (SCE), mi-cronucleus (MN) and 8-oxo-2-deoxyguanosine (8-OH-dG) assays were performed to determine genotoxic effect. In addition, total antioxidant capacity (TAC) and total oxidative stress (TOS) levels were measured as biochemical parameters. Our results clearly demonstrated that all tested concentrations of Na2B4O7.10H2O were not mutagenic. Moreover, Na2B4O7.10H2O showed antioxidant activities especially at low concentrations (< 40 mg/L) and the determined TOS levels did not change at all the concentrations of Na2B4O7.10H2O. As a result, our data clearly demonstrated that Na2B4O7.10H2O is non-genotoxic and it has a remarkable antioxidant potential in vitro.