Gold Nanoparticles and Reduced Graphene Oxide-Gold Nanoparticle Composite Materials as Covalent Drug Delivery Systems for Breast Cancer Treatment

JAFARIZAD A., AGHANEJAD A., SEVİM M., Metin O., BARAR J., OMIDI Y., ...Daha Fazla

CHEMISTRYSELECT, cilt.2, sa.23, ss.6663-6672, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2 Sayı: 23
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/slct.201701178
  • Dergi Adı: CHEMISTRYSELECT
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.6663-6672
  • Anahtar Kelimeler: Drug delivery, Gold, Graphene, Mitoxantrone, Nanostructures, SELF-ASSEMBLED MONOLAYERS, CHEMO-PHOTOTHERMAL THERAPY, SURFACE-ENHANCED RAMAN, MULTIDRUG-RESISTANCE, AU NANOPARTICLES, HYBRID MATERIALS, CELLS, NANOTECHNOLOGY, NANOCOMPOSITES, STABILITY
  • Atatürk Üniversitesi Adresli: Evet

Özet

AuNPs and AuNPs/RGO composites were engineered as drug delivery nanoplatforms to efficiently deliver the anti-cancer drug to MCF-7 breast cancer cells. The anti-cancer drug, mitoxantrone (MTX), was tethered to the gold nanoparticles via a 3-mercaptopropionic acid (MPA) spacer and an acid-cleavable amid bond (SMTX-AuNPs). Then, the surface of the RGO nanosheets were decorated with SMTX-AuNPs (SMTX-AuNPs/RGO). For comparison purposes, MPA functionalized nanoparticles (MPA-AuNPs) and their nanocomposites (MPA-AuNPs/RGO) were also prepared using the same procedure. The formation of the nanomaterials was verified by spectroscopic and morphological techniques. The drug delivery activity of materials on MCF-7 cells was investigated invitro using different methods. Our results demonstrate that SMTX-AuNPs have better activity on cancer cells than free MTX and SMTX-AuNPs/RGO. Further, contradicting previous studies, our findings suggest that the use of graphene-based materials for the covalent drug delivery systems need to be revisited.