Pigment epithelial-derived factor in the lens anterior capsule of patients with senile cataract with pseudoexfoliation.

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Utlu B., Akyol S., Öztürk N.

Clinical & experimental optometry, vol.103, pp.207-211, 2020 (SCI-Expanded, Scopus)

  • Publication Type: Article / Article
  • Volume: 103
  • Publication Date: 2020
  • Doi Number: 10.1111/cxo.12922
  • Journal Name: Clinical & experimental optometry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.207-211
  • Keywords: cataract, lens anterior capsule, lens epithelial cell, pigment epithelial-derived factor, pseudoexfoliation, DOWN-REGULATION, FIBER CELLS, EXPRESSION, GENE, PEDF, NUCLEAR, SERPIN
  • Open Archive Collection: AVESIS Open Access Collection
  • Ataturk University Affiliated: Yes

Abstract

Background: This study sought to evaluate pigment epithelial-derived factor (PEDF) levels

in lens anterior capsule material taken during cataract surgery from patients with senile cataract

with pseudoexfoliation.

Methods: The study included 90 eyes of 86 patients who were diagnosed with, and underwent

surgery for, cataracts. Sixty of the eyes included in the study had senile cataract. Thirty

eyes of 30 young patients with other forms of cataract were included as a control group.

Pseudoexfoliation was present in 21 patients with senile cataract. PEDF levels in the lens

anterior capsule material – extracted with capsulorhexis in the classical phacoemulsification

procedure – were measured by the enzyme-linked immunosorbent assay method and compared

between the groups.

Results: The PEDF level in the lens anterior capsule in the senile cataract patient group was

149.36 ! 17.46 pg/ml. A statistically significant lower level of PEDF was found in the lens

anterior capsule of patients with senile cataract compared with the other groups. In the

patient group with pseudoexfoliation, the PEDF level in the lens anterior capsule was found

to be statistically significantly lower than the patient group without pseudoexfoliation.

Conclusion: PEDF levels decrease with senile cataract and pseudoexfoliation. These findings

may clarify the pathogenesis of these conditions and point toward alternative treatment

modalities.