The association of human leukocyte antigenpolymorphisms with disease severity and latencyperiod in patients with silicosis


Doğan H., Akgün M., Araz Ö., Yılmazel Uçar E., Yörük Ö., Balkan E., ...More

Multidisciplinary Respiratory Medicine, vol.9, pp.1-6, 2014 (ESCI, Scopus)

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2014
  • Doi Number: 10.1186/2049-6958-9-17
  • Journal Name: Multidisciplinary Respiratory Medicine
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Page Numbers: pp.1-6
  • Keywords: HLA polymorphism, Immunity, Latency, Severity, Silicosis
  • Ataturk University Affiliated: Yes

Abstract

Background: Denim sandblasting may cause silicosis as a result of free crystalline silica inhalation. Its pathogenesis remains unclear, but autoimmunity may play a role in the development of silicosis. The present study aimed to investigate the relationships between human leukocyte antigen (HLA) and the severity and latency period of silicosis.