Protective effect of Coenzyme Q10 on oxidative ovarian and uterine damage induced by methotrexate in rats

Kiremitli T., Kiremitli S., Akselim B., Yilmaz B., Mammadov R., Tor I. H., ...Daha Fazla

HUMAN & EXPERIMENTAL TOXICOLOGY, cilt.40, sa.9, ss.1537-1544, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 9
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1177/09603271211002891
  • Dergi Adı: HUMAN & EXPERIMENTAL TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, Chimica, CINAHL, EMBASE, Environment Index, Food Science & Technology Abstracts, MEDLINE, Pollution Abstracts, Veterinary Science Database
  • Sayfa Sayıları: ss.1537-1544
  • Anahtar Kelimeler: Antioxidants, Coenzyme Q10, lipid peroxidation, methotrexate, oxidative stress
  • Atatürk Üniversitesi Adresli: Evet

Özet

Methotrexate (MTX) has toxic effects on the uterus and ovaries via oxidative stress. Coenzyme Q10 (CoQ10) is an important component in electron transport in the mitochondria and an antioxidant in cellular metabolism through the inhibition of lipid peroxidation. The aim of this study was to investigate the preventive effects of CoQ10 on MTX-induced utero-ovarian damage and oxidative stress in rats.