Synthesis of Pyridazine and Pyrrole Analogues of 2-Aminotetralin as Potential Dopaminergics
JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.55, sa.6, ss.1489-1493, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 55 Sayı: 6
- Basım Tarihi: 2018
- Doi Numarası: 10.1002/jhet.3180
- Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1489-1493
- Atatürk Üniversitesi Adresli: Evet
Özet
Syntheses of pyridazine and pyrrole analogues of 2-aminotetralin starting from 3-cyclohexene-1-carboxylic acid are reported. All syntheses involve the following key steps: Curtius rearrangement for amine functionality, inverse electron demand Diels-Alder addition with 1,2,4,5-tetrazine for pyridazine ring synthesis, and pyridazine-to-pyrrole ring contraction for pyrrole ring formation.