The effects of 3-benzoyl-1-methyl-4-phenyl-4-piperidinolhydrochloride (C1), indomethacin, nimesulide and rofecoxib on cyclooxygenase activities in carrageenan-induced paw edema model

ŞAHİN Y. N., Demircan B., SÜLEYMAN H., AKSOY H., GÜL H. İ.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.40, sa.5, ss.723-728, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3906/sag-0908-187
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.723-728
  • Atatürk Üniversitesi Adresli: Evet

Özet

Aim: The aim of this study was to investigate the effects of 3-benzoyl-1-methyl-4-phenyl-4-piperidinol-hydrochloride (C1) which is a structural and also non-classical isomer of bis Mannich base, bis (3-aryl-3-oxo-propyl) methylamine hydrochlorides (B1), on cyclooxygenase (COX) activities in 48 rats with inflammation by using carrageenan-induced paw edema, and to compare its effect with other non-steroidal anti-inflammatory drugs (NSAIDs).