Gastroprotective activity of Jervine alkaloid from Veratrum album on gastric ulcer in rat

Yigit S., Aydin T., Eyerci N., Yayla M., DUYSAK L., Necmiye Kaci F., ...Daha Fazla

Heliyon, cilt.11, sa.12, 2025 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 12
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.heliyon.2025.e43491
  • Dergi Adı: Heliyon
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, Food Science & Technology Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: Anti-inflammatory, Antioxidant, Jervine, Rat, Ulcer
  • Atatürk Üniversitesi Adresli: Evet

Özet

Aim: In this study, we investigated how Jervine affected gastric tissue in rats following the development of indomethacin-induced ulcers. Methods: Jervine (JER) 200 mg/kg and JER 400 mg/kg were given orally to the experimental groups 12h after the fasten period. Five minutes later, 25 mg/kg of indomethacin was administered orally to all groups except the healthy and JER 400 mg/kg groups. The experiment was concluded 6 h after the indomethacin. Results: The administration of Jervine at both doses resulted in a significant reduction of the ulcerative area compared to the Indomethacin (INDO). Indomethacin + Jervine 200 mg/kg (INDO + JER + 200 mg/kg) and Indomethacin + Jervine 400 mg/kg (INDO + JER + 400 mg/kg) groups significantly reduced apoptotic cell density compared to INDO group. Biochemically, Jervin decreased the Lipid Peroxidation (MDA) level which increased as a result of indomethacin. Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) levels, which decreased as a result of indomethacin, were found to increase. Jervine significantly downregulates p53 gene expression compared to the INDO group. Conclusion: In this study, we demonstrated the therapeutic properties of Jervine on ulcers due to its anti-apoptotic and antioxidant regulatory effects.