The relationship between estrogen receptors and microtubule dynamics in post-menopausal rat brain

Selina A. K., Murat K., Emre K., MALKOÇ İ., Bunyami U., Cemal G.

ACTA HISTOCHEMICA, cilt.117, sa.8, ss.747-751, 2015 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 117 Sayı: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.acthis.2015.08.005
  • Dergi Adı: ACTA HISTOCHEMICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.747-751
  • Anahtar Kelimeler: Axonal neurodegeneration, Estrogen receptors, HPIP, Microtubule, Ovariectomy, INTERACTING PROTEIN HPIP, MENOPAUSE, NEURODEGENERATION, ACTIVATION, PROTECTION, INCREASES, ESTRADIOL, BINDING, ALPHA, MODEL
  • Atatürk Üniversitesi Adresli: Evet

Özet

Introduction: Estrogen is one of the most important regulators of neuron function. There is a broad consensus that a loss of estrogen is associated with neurodegeneration in the hippocampus which leads to cognitive impairment. Hematopoietic-Pbx-interaction-protein (HPIP) is a novel scaffolding protein which interacts with microtubules and estrogen receptors. In this study, we investigated the presence and role of HPIP in hippocampal neurons and examined the relationship between estrogen receptors and microtubule damage in post-menopausal rat brains.