Synthesis of dimeric phenol derivatives and determination of in vitro antioxidant and radical scavenging activities

Gulcin I., Dastan A.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.22, sa.6, ss.685-695, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/14756360601164903
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.685-695
  • Anahtar Kelimeler: propofol, monophenol, diphenol, antioxidant activity, dimeric form, radical scavenging, OXIDATIVE DAMAGE, OXYGEN, FLAVONOIDS, EXTRACTS, L., INHIBITORS, TOXICITY, DISEASE, BIOLOGY, ACID
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, di(2,6-dimethylphenol) (Di-DMP), di(2,6-diisopropylphenol) (Di-DIP, dipropofol) and di( 2,6-di-t-butylphenol) (Di-DTP) were synthesized by the reaction of monomeric phenol derivatives with catalytic CuCl( OH). TMEDA and Na2S2O4. Their antioxidant capacity and radical scavenging activity were examined using different in vitro methodologies such as 1,1-diphenyl- 2-picryl-hydrazyl (DPPH center dot) free radical scavenging, 2,2'-azino-bis(3-ethylbenzthiazoline6- sulfonic acid) (ABTS) radical scavenging activity, total antioxidant activity by ferric thiocyanate, total reducing power by potassium ferricyanide reduction method, superoxide anion radical scavenging, hydrogen peroxide scavenging and ferrous ions chelating activities.