Evaluation of xanthine oxidase inhibitor properties on isoindoline-1,3-dion derivatives and calculation of interaction mechanism

Gundugdu O., Noma S. A. A., TAŞKIN TOK T., ATEŞ B., KİSHALI N.

JOURNAL OF MOLECULAR STRUCTURE, cilt.1204, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1204
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.molstruc.2019.127523
  • Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, INSPEC
  • Anahtar Kelimeler: Isoindoline-1,3-dione, Phthalimide, Xanthine oxidase, Molecular docking, Biological activity, BIOLOGICAL EVALUATION, MOLECULAR DOCKING, BINDING SITE, IN-VITRO, DESIGN, POTENT, SERIES
  • Atatürk Üniversitesi Adresli: Evet

Özet

The aim of the present study was to synthesis of isoindole-1,3(2H)-dione (Phthalimides) derivatives and to investigation the inhibition of xanthine oxidase (XO). In study, xanthine oxidase inhibitory activities of complexes were observed in the range from 7.15 to 22.56 mu M for isoindole-1,3-dione (2a-c and 3a-c). N-phenyl isoindole-1,3-dione derivatives (2c, 3c) showed better activity (almost two times) than the other two derivatives (N-methyl (2a, 3a), N-ethyl (2b, 3b). It means that phenyl ring (R) remarkably enhances the xanthine oxidase inhibitory effect of complexes. In the meantime, molecular docking studies of these compounds against XO were also investigated by providing the inhibitory efficiency and estimating the interaction mechanisms of isoindol-1,3-dion derivatives with XO. (C) 2019 Elsevier B.V. All rights reserved.