Synthesis, Characterization, and Antibacterial Activity of Novel Pyridones

GEZEGEN H., CEYLAN M., KARAMAN İ., ŞAHİN E.

SYNTHETIC COMMUNICATIONS, cilt.44, sa.8, ss.1084-1093, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 8
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1080/00397911.2013.845902
  • Dergi Adı: SYNTHETIC COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1084-1093
  • Atatürk Üniversitesi Adresli: Evet

Özet

Novel ethyl 2-oxo-4,6-diaryl-1,2,3,4-tetrahydropyridine-3-carboxylate and 4,6-diaryl-3,4-dihydropyridine-2(1H)-one derivatives have been synthesized from the cyclization of adducts of diethylmalonate to chalcones with ammonium acetate. The structures were established on the basis of extensive spectroscopic methods and further confirmed by X-ray crystallographic analysis. Antibacterial activity of obtained pyridones was investigated against four human pathogen microorganisms and the compounds showed poor activity.