Akademik Veri Yönetim Sistemi
RADIOCHIMICA ACTA, cilt.113, sa.10, ss.805-817, 2025 (SCI-Expanded)
Gamma rays are highly penetrating ionizing electromagnetic radiation, and this property has made them widely used in various industrial applications. Major areas of application for gamma rays include radiotherapy, nuclear energy, materials science, the petroleum and natural gas industry, space research, sterilization, and disinfection. However, when gamma rays interact with living cells, they can increase the formation of free radicals, leading to cell death and structural damage. Additionally, gamma rays can weaken the immune system, trigger oxidative stress and inflammation, and cause pain. In this context, there is a significant need for protective substances to minimize the biological damage caused by gamma radiation exposure. Zingerone, one of the active compounds in ginger, has strong antioxidant properties and can limit cellular damage by combating free radicals. Ibuprofen, with its anti-inflammatory properties, may help reduce inflammation and oxidative damage. Sulfasalazine, on the other hand, regulates excessive immune responses, preventing the development of inflammatory diseases such as rheumatoid arthritis and spondylarthritis, and can also limit the negative effects of gamma radiation on the immune system. This study investigates the potential of zingerone, ibuprofen, and sulfasalazine as active ingredients for developing protective drugs against gamma radiation. The interactions of these compounds with gamma rays were explored both theoretically and experimentally. Key absorption parameters for gamma rays, such as mass attenuation coefficient, linear attenuation coefficient, half-value layer, mean free path, and effective atomic number, were calculated using the WinXCom program. Gamma radiation absorption experiments were conducted using radioactive sources, including 100 mCi of Am-241 (with a specific activity of 1.27 x 1011 Bq/g or 3.44 Ci/g), 13 Ci of Ba-133 (with a specific activity of 629 GBq/g or 13 Ci/g), and 0.081 mu Ci of Cs-137 (with a specific activity of 3.2 x 1012 Bq/g). These sources emit photons in the energy range of 0.0139 MeV-0.6620 MeV, and the measurements were carried out using an ultra-high purity germanium (HPGe) detector. The experimental and theoretical data were compared. The results show that all samples have the capacity to absorb gamma radiation. Notably, sulfasalazine (DA3) exhibited a higher gamma radiation absorption capacity than the other compounds. This finding suggests that the investigated compounds can be used as active ingredients in the development of protective drugs against gamma radiation.