Research Information System
in: Congenital Anomalies of the Eye and its Adnexa, Nurettin Karakaş, Editor, Turkiye Klinikleri, Ankara, pp.20-24, 2024
ABSTRACT The iris is the anterior part of the uveal layer of the eye. It protects the retina from pho- totoxic effects by adjusting the amount of light entering the eye. It occurs during the 5th intrauterine week when the neural crest cells on the back surface of the cornea undergo changes. While the iris stroma develops from neural crest cells, two epithelial layers consist of neuroectodermal tissue at the edge of the optic fossa. Congenital anomalies of the iris are often seen together with anomalies of other structures of the anterior segment due to their common embryological development. For example, as in Axenfeld-Rieger syndrome and Peters anomaly. The most common congenital iris anomalies are iris colobomas, aniridia and heterochromic iris.
Keywords: Congenital abnormalities; coloboma; aniridia