EVALUATION OF ANTI-OXIDATIVE, ANTI-MUTAGENIC POTENCY OF THE METHANOLIC EXTRACT FROM ULOTRIX CYLINDRICUM

AĞAR G., GÜLLÜCE M., Alpsoy L., GÜRBÜZ H., KARADAYI M., KOTAN E.

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.20, sa.6, ss.1366-1373, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 6
  • Basım Tarihi: 2011
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1366-1373
  • Atatürk Üniversitesi Adresli: Evet

Özet

Algae are potentially productive sources of highly bioactive secondary metabolites that might be useful in the development of new pharmaceutical agents. In this study, methanolic extract from Ulotrix cylindricum (UME) was investigated for anti-mutagenicity/anti-genotoxicity properties by using the AMES/Salmonella system, sister chromatid exchange (SCE) and micronuclei (MN) assay. Also we aimed to determine the anti-oxidative effects of UME against aflatoxin B(1) (AFB(1)) in human lymphocyte cell culture in vitro by using superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA) assay. The results show that UME (10 mu g/ml) has an antimutagenic effect in all three test systems. UME caused significant increases in the level of GSH as well as the activities of SOD and GPx at the concentrations of 5 and 10 mu g/ml. In addition, the level of MDA decreased at the concentrations of 5 and 10 mu g/ml. According to the findings, UME has strong anti-oxidative and anti-genotoxic effects.