Effect of glimepiride on paraoxonase activity

Demir Y., Nadaroglu H., Demir N.

PHARMACEUTICAL BIOLOGY, cilt.44, sa.5, ss.396-399, 2006 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44 Sayı: 5
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/13880200600751717
  • Dergi Adı: PHARMACEUTICAL BIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.396-399
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, the effect of glimepiride on serum paraoxonase activity (EC 3.1.8.1.) has been investigated in vitro . The inhibition and activation effects of this drug on serum paraoxonase activity was measured spectrophotometrically using paraoxon as the substrate. The phenotypic distribution of paraoxonase was determined using the dual substrate paraoxon and phenyl acetate as substrates. It was observed that glimepiride inhibited serum paraoxonase activity. In addition, an in vivo study was performed for glimepiride in Sprague-Dawley rats. It was demonstrated that paraoxonase in serum, liver, and heart of Sprague-Dawley rat was significantly inhibited.