The protective effects of naringin against 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats

Gelen V., ŞENGÜL E., YILDIRIM S., Atila G.

Iranian Journal of Basic Medical Sciences, cilt.21, sa.4, ss.404-410, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2018
  • Doi Numarası: 10.22038/ijbms.2018.27510.6714
  • Dergi Adı: Iranian Journal of Basic Medical Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.404-410
  • Anahtar Kelimeler: 5-fluorouracil, Hepatotoxicity, Naringin, Nephrotoxicity, Rat, ANTIOXIDANT ACTIVITY, OXIDATIVE DAMAGE, DOXORUBICIN, QUERCETIN, LIVER, CISPLATIN, CARDIOTOXICITY, CHEMOTHERAPY, BIOMARKERS, CYTOKINES
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective(s): 5-fluorouracil-induced (5-FU), an anticarcinogenic agent, is reported to have side-effects that include hepatotoxicity and nephrotoxicity. The study objective was to investigate the protective effects of naringin on 5-FU-induced hepatotoxicity and nephrotoxicity.