The Importance of Heat Shock-Related 70-kDa Protein 2 Expression in Laryngeal Squamous Cell Carcinomas

CEYLAN O., ARSLAN R.

EURASIAN JOURNAL OF MEDICINE, cilt.54, sa.2, ss.165-172, 2022 (ESCI) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5152/eurasianjmed.2022.21113
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.165-172
  • Anahtar Kelimeler: Laryngeal squamous cell carcinoma, heat shock proteins, HSPA-2, immunoreactivity, prognostic importance, CANCER, HSPA2, HSP70-2, GROWTH
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: Laryngeal squamous cell carcinoma has a high mortality rate, and approximately 60% of patients are in advanced stage at the time of diagnosis. Thus, determining the prognostic parameters of this cancer and markers related to these parameters are very important. There are studies showing that heat shock-related 70-kDa protein 2, which is used as a biomarker, may be associated with prognostic parameter in some cancers. However, no study has investigated the prognostic role of heat shock-related 70-kDa protein 2 in laryngeal squamous cell carcinoma in the literature. Thus, in our study, the aim was to examine the relationship between heat shock-related 70-kDa protein 2 expression and clinicopathological prognostic parameters in laryngeal squamous cell carcinoma.