Synephrine and phenylephrine act as -amylase, -glycosidase, acetylcholinesterase, butyrylcholinesterase, and carbonic anhydrase enzymes inhibitors

TASLIMI P., Akincioglu H., GÜLÇİN İ.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, cilt.31, sa.11, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 11
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/jbt.21973
  • Dergi Adı: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: alpha-amylase, alpha-glycosidase, carbonic anhydrase, phenylephrine, synephrine, ALPHA-GLUCOSIDASE INHIBITORS, ERYTHROCYTES IN-VITRO, HRMS-SPE-NMR, ISOENZYMES I, ANTIOXIDANT, ACID, PROFILES, IDENTIFICATION, DERIVATIVES, BIOACTIVITY
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this paper, synephrine and phenylephrine compounds showed excellent inhibitory effects against human carbonic anhydrase (hCA) isoforms I and II, -amylase, -glycosidase, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE). Synephrine and phenylephrine had K-i values of 199.02 +/- 16.01 and 65.01 +/- 5.00M against hCA I and 336.02 +/- 74.01 and 92.04 +/- 18.03M against hCA II, respectively. On the other hand, their K-i values were found to be 169.10 +/- 80.03 and 88.03 +/- 5.01nM against AChE and 177.06 +/- 6.01 and 78.03 +/- 3.05nM against BChE, respectively. -Amylase and -glycosidase enzymes were easily inhibited by these compounds. -Glycosidase inhibitors, generally defined to as starch blockers, are anti-diabetic drugs that help to decrease post comestible blood glucose levels.