Possible contribution of the neprilysin/ACE pathway to sepsis in mice

Uğan, Rüstem; Un, Harun; Gurbuz, Muhammet; Kaya, Gokce; Kahramanlar, Aysenur; Aksakalli-Magden, Zeynep; Halıcı, Zekai; Çadırcı, Elif

doi:10.1016/j.lfs.2020.118177

Possible contribution of the neprilysin/ACE pathway to sepsis in mice

Uğan R. A., Un H., Gurbuz M. A., Kaya G., Kahramanlar A., Aksakalli-Magden Z. B., ...Daha Fazla

LIFE SCIENCES, cilt.258, 2020 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 258
Basım Tarihi: 2020
Doi Numarası: 10.1016/j.lfs.2020.118177
Dergi Adı: LIFE SCIENCES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, Chimica, EMBASE, MEDLINE, Veterinary Science Database
Anahtar Kelimeler: Omapatrilat, Sepsis, Mice, ACE, Neprilysin, ATRIAL-NATRIURETIC-PEPTIDE, ANGIOTENSIN-CONVERTING ENZYME, ACUTE LUNG INJURY, VASOPEPTIDASE INHIBITOR OMAPATRILAT, ACUTE RESPIRATORY-DISTRESS, RAT MODEL, PERMEABILITY, CANDESARTAN, INFARCTION, CYTOKINES
Atatürk Üniversitesi Adresli: Evet

Özet

Aim: Omapatrilat is an antagonist of angiotensin-converting (ACE) and neprilysin-neuropeptidase (NEP) enzymes. The aim of our study is to show that omapatrilat may have beneficial effects as a treatment for polymicrobial sepsis.