Systems biology based drug repositioning for development of cancer therapy.

Turanli B., Altay O., Borén J., Turkez H., Nielsen J., Uhlen M., ...Daha Fazla

Seminars in cancer biology, cilt.68, ss.47-58, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.semcancer.2019.09.020
  • Dergi Adı: Seminars in cancer biology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.47-58
  • Anahtar Kelimeler: Systems biology, Cancer, Drug repositioning, Signature-based approaches, Network-based approaches, PROTON PUMP INHIBITORS, COLORECTAL-CANCER, ANALYSIS REVEALS, NETWORK, PROTEIN, SIGNATURES, IDENTIFY, TARGETS, DISCOVERY, ASPIRIN
  • Atatürk Üniversitesi Adresli: Evet

Özet

Drug repositioning is a powerful method that can assists the conventional drug discovery process by using existing drugs for treatment of a disease rather than its original indication. The first examples of repurposed drugs were discovered serendipitously, however data accumulated by high-throughput screenings and advancements in computational biology methods have paved the way for rational drug repositioning methods. As chemotherapeutic agents have notorious side effects that significantly reduce quality of life, drug repositioning promises repurposed noncancer drugs with little or tolerable adverse effects for cancer patients. Here, we review current drug-related data types and databases including some examples of web-based drug repositioning tools. Next, we describe systems biology approaches to be used in drug repositioning for effective cancer therapy. Finally, we highlight examples of mostly repurposed drugs for cancer treatment and provide an overview of future expectations in the field for development of effective treatment strategies.