Atıf İçin Kopyala
Dostbil A., Atalay C., Ince I., Aksoy M., Ozmen O., Kasali K., ...Daha Fazla
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, cilt.50, sa.11, 2023 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
50
Sayı:
11
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Basım Tarihi:
2023
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Doi Numarası:
10.31083/j.ceog5011241
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Dergi Adı:
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
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Anahtar Kelimeler:
caesarean section, hemodynamics, low dose bupivacaine, spinal anaesthesia
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Atatürk Üniversitesi Adresli:
Evet
Özet
Background: The objective of this study was to conduct a randomized controlled trial in order to examine the hemodynamic impacts of two different doses of intrathecal isobaric bupivacaine (5 mg and 7 mg) when combined with 15 mu g fentanyl in the context of patients undergoing caesarean section under combined spinal epidural anesthesia. Methods: Eighty patients with American Society of Anesthesiologists physical status I and II, aged between 16-50 years, who would undergo elective caesarean section under combined spinal epidural anaesthesia were randomly allocated to Group A and Group B (n = 40, for each group). Group A patients received a solution containing 5 mg isobaric bupivacaine + 15 mu g fentanyl (1.3 mL), while Group B patients received a solution containing 7 mg isobaric bupivacaine + 15 mu g fentanyl (1.7 mL) intrathecally. Incidences of hypotension, intraoperative systolic blood pressure, diastolic blood pressure, heart rate, motor block resolving time, and analgesia duration were recorded. Results: Group A had a substantially lower incidence of hypotension than Group B (p = 0.022). Patients in Group B had significantly lower systolic blood pressure values at the 6th, 8th, 10th, 12th, 14th, 15th, and 30th minutes of the surgery compared to Group A (p = 0.012, p = 0.014, p = 0.005, p = 0.016, p << 0,001, p = 0.002, and p = 0.011; respectively). Both groups had similar diastolic blood pressure and heart rate values during surgery (p >> 0.05). The motor block resolving time and analgesia duration were longer in Group B compared to Group A (p << 0.001 for both). Two (5%) patients in Group A and ten (25%) patients in Group B experienced postoperative itching (p = 0.012). Conclusions: We concluded that combining 5 mg isobaric bupivacaine with 15 mcg of fentanyl administered intrathecally provides adequate anaesthesia while maintaining better hemodynamic stability in patients undergoing caesarean section.