A facile synthesis and antibacterial activity of novel pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides

Largani T. H., Imanzadeh G., Zahri S., Pesyan N. N., ŞAHİN E.

GREEN CHEMISTRY LETTERS AND REVIEWS, cilt.10, sa.4, ss.387-392, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/17518253.2017.1380233
  • Dergi Adı: GREEN CHEMISTRY LETTERS AND REVIEWS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.387-392
  • Anahtar Kelimeler: Pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides, molecular hybridization, antibiotic resistance, minimum inhibitory concentration, eco-friendly approach, QUINOLINES, ALKALOIDS, CAMPTOTHECIN, DESIGN, AGENTS, ACID, TOOL
  • Atatürk Üniversitesi Adresli: Evet

Özet

A new series of pyrrolo[3,4-b]quinolin-2(3H)-yl)benzamides were designed based on molecular hybridization approach and synthesized by reaction of benzohydrazide derivatives with 9-phenylfuro[ 3,4-b] quinoline-1,3-diones in the presence of an Et3N catalyst. Simple reaction, excellent yield, simple separation process and eco-friendly approach by minimizing the chemical waste renders this protocol particularly attractive. The series 9a-g was evaluated for in vitro antibacterial activity against (+ve bacteria) Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212, (-ve bacterium) Escherichia coli ATCC 25922. In vitro minimum inhibitory concentration (MIC) evaluations showed that the compound 9a was effective against E. coli (MIC: 0.25 mg/mL) S. aureus (MIC: 0.25 mg/mL) and E. faecalis (MIC: 0.5 mg/mL).