The lung endothelin system: a potent therapeutic target with bosentan for the amelioration of lung alterations in a rat model of diabetes mellitus


CAYIR A., UĞAN R. A. , ALBAYRAK A. , KÖSE D. , AKPINAR E. , ÇAYIR Y. , et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, cilt.38, ss.987-998, 2015 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 38 Konu: 9
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s40618-015-0282-y
  • Dergi Adı: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Sayfa Sayısı: ss.987-998

Özet

Purpose The aim of this study is to show the effect of a new mechanism on endothelin (ET) receptors in the physiopathology of diabetes-related pulmonary injury. We tested the hypothesis that dual ET-1 receptor antagonism via bosentan can reverse diabetes-induced lung injury.