The lung endothelin system: a potent therapeutic target with bosentan for the amelioration of lung alterations in a rat model of diabetes mellitus

CAYIR, A.; UĞAN, Rüstem; ALBAYRAK, Abdulmecit; KÖSE, Duygu; AKPINAR, Erol; ÇAYIR, Yasemin; Atmaca, H.; BAYRAKTUTAN, Zafer; KARA, Murat

doi:10.1007/s40618-015-0282-y

The lung endothelin system: a potent therapeutic target with bosentan for the amelioration of lung alterations in a rat model of diabetes mellitus

CAYIR A., UĞAN R. A., ALBAYRAK A., KÖSE D., AKPINAR E., ÇAYIR Y., ...Daha Fazla

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, cilt.38, sa.9, ss.987-998, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 38 Sayı: 9
Basım Tarihi: 2015
Doi Numarası: 10.1007/s40618-015-0282-y
Dergi Adı: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.987-998
Anahtar Kelimeler: Bosentan, Lung injury, Endothelin system, Diabetes, RECEPTOR ANTAGONIST BOSENTAN, OXIDATIVE STRESS, POLYMICROBIAL SEPSIS, ETA-RECEPTOR, NITRIC-OXIDE, DOUBLE-BLIND, COMPLICATIONS, DYSFUNCTION, TISSUE, EXPRESSION
Atatürk Üniversitesi Adresli: Evet

Özet

Purpose The aim of this study is to show the effect of a new mechanism on endothelin (ET) receptors in the physiopathology of diabetes-related pulmonary injury. We tested the hypothesis that dual ET-1 receptor antagonism via bosentan can reverse diabetes-induced lung injury.