A facile and regioselective one-pot synthesis of novel pyrazolo[1,5:1,2]pyrrolo[3,4-b]quinoline-2,3-dicarboxylate hybrids via intramolecular Wittig reaction

LARGANİ T. H., IMANZADEH G., PESYAN N. N., ŞAHİN E., SHAMKHALİ A. N., NOTASH B.

MOLECULAR DIVERSITY, cilt.22, sa.1, ss.37-46, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1007/s11030-017-9784-1
  • Dergi Adı: MOLECULAR DIVERSITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.37-46
  • Anahtar Kelimeler: Regioselective, One-pot synthesis, Pyrrolo[3,4-b]quinoline, Wittig reaction, Pyrazole, Hybrid molecules, SOLVENT-FREE CONDITIONS, PYRAZOLE DERIVATIVES, PHOSPHORUS YLIDES, EFFICIENT, DENSITY, DESIGN, DRUG
  • Atatürk Üniversitesi Adresli: Evet

Özet

The regioselective syntheses of novel pyrazolo[1,5:1,2]pyrrolo[3,4-b]quinoline-2,3-dicarboxylates (6a-l) from pyrrolo([3,4-b]quinolin-2(3H)-yl)benzamides through an intramolecular Wittig reaction are described. This protocol takes advantages of mild conditions, simple workup and high yield which make this method attractive for the synthesis of these hybrid of pyrazolo[1,5:1,2]pyrrolo[3,4-b]quinolines.