Cognitive functions and serum levels of brain-derived neurotrophic factor in patients with major depressive disorder

ORAL E., Canpolat S., YILDIRIM S., Gulec M., Aliyev E., Aydin N.

BRAIN RESEARCH BULLETIN, cilt.88, sa.5, ss.454-459, 2012 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 88 Sayı: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.brainresbull.2012.03.005
  • Dergi Adı: BRAIN RESEARCH BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.454-459
  • Anahtar Kelimeler: Brain-derived neurotrophic factor, Cognitive functions, Depression, HIPPOCAMPAL VOLUME, ALZHEIMERS-DISEASE, BIPOLAR DISORDER, MEMORY FORMATION, SPATIAL MEMORY, MESSENGER-RNA, FACTOR BDNF, IMPAIRMENT, MICE, TERM
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: We assessed major cognitive domains in major depressive disorder (MDD) compared to a healthy control group using neurocognitive tests. We hypothesized that lower serum brain-derived neurotrophic factor (BDNF) levels would be associated with poorer neurocognitive performance in patients with major depression and that these associations would be shown in healthy controls as well.