Effect of adenosine triphosphate, benidipine and their combinations on bevacizumab-induced kidney damage in rats.

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Kocaturk H., Bedir F., Turangezli Ö., Arslan R., Çoban T. A., Altuner D., ...Daha Fazla

Advances in clinical and experimental medicine : official organ Wroclaw Medical University, cilt.30, 2021 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 30
• Basım Tarihi: 2021
• Doi Numarası: 10.17219/acem/140440
• Dergi Adı: Advances in clinical and experimental medicine : official organ Wroclaw Medical University
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
• Anahtar Kelimeler: bevacizumab, rat, nephrotoxicity, ATP, benidipine, OXIDATIVE STRESS, CALCIUM, TISSUE, HYDROCHLORIDE, ANTIOXIDANTS, MELATONIN, RADICALS, INJURY
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Atatürk Üniversitesi Adresli: Evet

Özet

Background. Bevacizumab-induced vascular endothelial growth factor (VEGF) inhibition may lead to a decrease in adenosine triphosphate (ATP) levels, an increase in intracellular Na+ and Ca2+ concentrations and an increase in reactive oxygen species (ROS) generation, as well as to cell damage.