Effect of adenosine triphosphate, benidipine and their combinations on bevacizumab-induced kidney damage in rats.

Kocaturk, Hüseyin; Bedir, Fevzi; Turangezli, Ömer; Arslan, Remzi; Çoban, Taha; Altuner, Durdu; Suleyman, Halis

doi:10.17219/acem/140440

Effect of adenosine triphosphate, benidipine and their combinations on bevacizumab-induced kidney damage in rats.

Kocaturk H., Bedir F., Turangezli Ö., Arslan R., Çoban T. A., Altuner D., ...More

Advances in clinical and experimental medicine : official organ Wroclaw Medical University, vol.30, 2021 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 30
Publication Date: 2021
Doi Number: 10.17219/acem/140440
Journal Name: Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
Keywords: bevacizumab, rat, nephrotoxicity, ATP, benidipine, OXIDATIVE STRESS, CALCIUM, TISSUE, HYDROCHLORIDE, ANTIOXIDANTS, MELATONIN, RADICALS, INJURY
Open Archive Collection: AVESIS Open Access Collection
Ataturk University Affiliated: Yes

Abstract

Background. Bevacizumab-induced vascular endothelial growth factor (VEGF) inhibition may lead to a decrease in adenosine triphosphate (ATP) levels, an increase in intracellular Na+ and Ca2+ concentrations and an increase in reactive oxygen species (ROS) generation, as well as to cell damage.