Evaluation of Ozone Therapy Effectiveness by the Red Cell Distribution Width/Albumin Ratio

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KOÇAK M. B., Nas M. A., YILMAZ İ. B.

The European Research Journal, cilt.12, sa.9, ss.1023-1030, 2026 (TRDizin)

Özet

Objective: Ozone is an inorganic gas utilized for medical purposes. Ozone therapy has gained increasing popularity in recent years and is employed in the treatment of chronic diseases associated with inflammation. The red cell distribution width/albumin ratio (RAR) has recently emerged as an inflammatory marker. The aim of this study was to evaluate the efficacy of ozone therapy in patients with spinal pain and to investigate the effect of ozone therapy on inflammation through changes in the RAR value. Methods: This prospective pilot study was conducted in a pre- and post-treatment design on patients with spinal pain. In addition to demographic data, visual analog scale (VAS) scores and RAR values were recorded before and after ozone therapy. All patients underwent major ozone autohemotherapy. Data were analyzed using the SPSS software. Results: During the study period, 93 patients presented to the ozone therapy unit. After applying the exclusion criteria, 66 patients were included in the analysis. The mean (SD) pretreatment VAS score was 6.74 (1.53), while the mean (SD) posttreatment VAS score was 4.08 (1.54) (P < .05). The mean (SD) pretreatment RAR value was 3.37 (0.64), which decreased to 3.14 (0.50) following ozone therapy (P < .05). Conclusion: Our findings demonstrate that major ozone autohemotherapy is effective in alleviating spinal pain. Furthermore, the reduction in RAR values before and after treatment indicates that major ozone autohemotherapy exerts an anti-inflammatory effect.