Determination of Naproxen using derivatization with MSTFA in pharmaceuticalpreparations by GC-MS method

Yılmaz B., Turan Ö., Yılmaz S., Kadıoğlu Y.

NanoEra, cilt.4, sa.1, ss.1-5, 2024 (Hakemli Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 1
  • Basım Tarihi: 2024
  • Dergi Adı: NanoEra
  • Sayfa Sayıları: ss.1-5
  • Atatürk Üniversitesi Adresli: Evet

Özet

This work reports the using of N-methyl-N-(trimethylsilyl) trifluoroacetamide for the derivatization of naproxen and the GC-MS method for naproxen detection in pharmaceutical preparations. The linearity of the GC-MS technique was proven over the concentration range of 0.5-12 µg/mL. There was less than 1.20 and 1.73% for the intra- and inter-day relative standard deviation, respectively. For the GC-MS technique, the limits of detection and quantification were established at 0.05 and 0.15 µg/mL. The developed technique was used to analysis tablets of a pharmaceutical preparation called Aleve. At the chosen assay conditions, tablet excipients did not cause any interference.