Removal of the toxic effects of chlormadinon acetate on the development of Drosophila melanogaster via the use of nordihydroguaiaretic acid

Altun D., UYSAL H., Ayar A., AŞKIN H.

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.27, sa.1, ss.29-33, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1177/0748233710380216
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.29-33
  • Anahtar Kelimeler: Drosophila melanogaster, chlormadinone acetate, nordihydroguaiaretic acid, developmental stages, toxicity, CONTRACEPTIVE STEROIDS, INHIBITOR, CELLS, RATS, MICE
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, the effects of chlormadinon acetate (CMA) and CMA + nordihydroguaiaretic acid (NDGA) on various developmental stages of Drosophila melanogaster were investigated. Different concentrations of CMA (1.0; 3.0; 5.0 and 10.0 mu M/100 mL medium) and CMA + NDGA as the concentrations of CMA (1.0 + 1.0; 3.0 + 3.0; 5.0 + 5.0 and 10.0 + 10.0 mu M/100 mL medium) were carried out during the developmental periods of the flies. When F-1 progeny of control and application groups were compared, CMA was found to extend the process of metamorphosis and decrease the total offspring numbers. However, these negative effects were inhibited by NDGA treatment at different concentrations. These results suggest that NDGA could effectively inhibit CMA-induced abnormalities in developmental stages of D. melanogaster. It was found that the difference between the groups was significantly important (p < 0.05).