Simultaneous determination of arbutin and its decomposed product hydroquinone in whitening creams using high-performance liquid chromatography with photodiode array detection: Effect of temperature and pH on decomposition

Jeon, J.; Kim, B.; Lee, S.; Kwon, H.; Bae, H.; Kim, S.; Park, J.; Shim, J.; Abd El-Aty, ABDELATY; Shin, H.

doi:10.1111/ics.12228

Simultaneous determination of arbutin and its decomposed product hydroquinone in whitening creams using high-performance liquid chromatography with photodiode array detection: Effect of temperature and pH on decomposition

Atıf İçin Kopyala

Jeon J. S., Kim B. H., Lee S. H., Kwon H. J., Bae H. J., Kim S. K., ...Daha Fazla

INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, cilt.37, sa.6, ss.567-573, 2015 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 37 Sayı: 6
Basım Tarihi: 2015
Doi Numarası: 10.1111/ics.12228
Dergi Adı: INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.567-573
Anahtar Kelimeler: arbutin, high-performance liquid chromatography, hydroquinone, temperature, whitening cosmetics, COSMETIC PRODUCTS, SPECTROMETRIC METHOD, KOJIC ACID, AGENTS, SAFETY, PHOTOSTABILITY, VALIDATION, ETHERS, HPLC
Atatürk Üniversitesi Adresli: Hayır

Özet

OBJECTIVE: Arbutin is an effective agent for the treatment of melanin disorders. Arbutin may be converted to hydroquinone under conditions of high temperature, ultraviolet (UV) radiation and dilute acid. The aim of the current study was to develop an analytical method to determine the levels of arbutin and hydroquinone in whitening cosmetic products using high-performance liquid chromatography with photodiode array detection (HPLC-DAD). In addition, we investigated the effects of high temperature and pH on the decomposition of arbutin.