IN VITRO EVALUATION OF PLANT HYDROSOLS IN ENHANCING THE ANTIMICROBIAL ACTIVITY OF ANTIBIOTICS AGAINST FISH-BORNE PATHOGENS, LISTERIA MONOCYTOGENES, AND STAPHYLOCOCCUS AUREUS
16 TH INTERNATIONAL AZERBAIJAN CONGRESS ON LIFE, ENGINEERING, MATHEMATICAL, AND APPLIED SCIENCES, Baku, Azerbaycan, 20 Eylül - 22 Ekim 2026, ss.627-635, (Tam Metin Bildiri)
- Yayın Türü: Bildiri / Tam Metin Bildiri
- Basıldığı Şehir: Baku
- Basıldığı Ülke: Azerbaycan
- Sayfa Sayıları: ss.627-635
- Atatürk Üniversitesi Adresli: Evet
Özet
Aquatic organisms obtained through both capture fisheries and aquaculture now account for nearly one-
quarter of global animal protein consumption, but fish-borne infections have emerged as a problem both
for the producers and consumers with this increase in aquaculture production. Transmission of some
various microorganisms like bacteria, parasites, and viruses from raw or undercooked fish or seafood to
human resulted with fish-borne diseases that mostly causes gastrointestinal and allergic infections. As
with all bacterial diseases, antibiotics are frequently used to treat fish-borne infections. However,
because intensive antibiotic use leads to bacterial resistance, the expected therapeutic benefits are not
always achieved, and the efficacy of certain antibiotics remains very limited. Measures such as
shortening the treatment duration or using the minimum dose of the antibiotic that is better tolerated by
the body can reduce this resistance. The aim of this study is to determine whether the activity of
antibiotics used against selected significant fish-borne pathogens can be enhanced by combining them
with various plant hydrosols. For this purpose, the effects of hydrosols obtained via hydrodistillation
from the plants Rosa canina, Artemisia absinthium, Vitex agnus-castus, Hypericum perforatum, and
Lavandula officinalis on the antimicrobial activity of selected antibiotics, (oxytetracycline, amoxicillin,
flumequine, trimethoprim/sulfamethoxazole, oxolinic acid, gentamicin, tetracycline, chloramphenicol,
enrofloxacin, and erythromycin) were investigated against Listeria monocytogenes and Staphylococcus
aureus, bacteria known to be important fish-borne pathogens. The study determined that the antibacterial
activities of the antibiotics increased in a pathogen-specific manner when combined with hydrosols. The
trimethoprim/sulfamethoxazole combination demonstrated high efficacy against L. monocytogenes in
all hydrosols, whereas against S. aureus, it was effective only in combination with R. canina. Against
L. monocytogenes, oxytetracycline (R. canina), tetracycline (V. agnus-castus, H. perforatum), and
erythromycin (H. perforatum) showed increased activity. Against S. aureus, oxolinic acid (V. agnus-
castus, H. perforatum, L. officinalis), as well as tetracycline (R. canina, A. absinthium) chloramphenicol (R. canina, A. absinthium, L. officinalis) and enrofloxacin (R. canina), significantly enhanced the
antibacterial effect.