Therapeutic potential of casticin in alleviating ovarian torsion/ detorsion-induced ovarian and lung injuries
Iranian Journal of Basic Medical Sciences, cilt.28, sa.8, ss.1057-1064, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 28 Sayı: 8
- Basım Tarihi: 2025
- Doi Numarası: 10.22038/ijbms.2025.85990.18572
- Dergi Adı: Iranian Journal of Basic Medical Sciences
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Index Islamicus, Veterinary Science Database, Directory of Open Access Journals
- Sayfa Sayıları: ss.1057-1064
- Anahtar Kelimeler: Casticin, Lung, Ovary, Rat, Torsion Detorsion
- Atatürk Üniversitesi Adresli: Evet
Özet
A B S T R A C T Objective(s): Ovarian torsion is a critical gynecological emergency caused by the twisting of the ovary around its supporting structures, resulting in compromised blood flow and potential ovarian damage. Ovarian torsion/detorsion (T/D) can lead to severe complications, including infertility, if not promptly addressed. This study aimed to investigate the therapeutic effects of casticin (CAST) on ovarian and lung tissue injuries induced by a bilateral ovarian T/D model in rats. Materials and Methods: Experimental animals were randomly allocated into groups of sham, T/D, CAST 5 mg/kg, and CAST 10 mg/kg. Ovarian and lung tissues were subjected to biochemical, histopathological, and immunohistochemical analyses. Results: In the T/D group, markers of oxidative stress and inflammation, including myeloperoxidase (MPO) activity, malondialdehyde (MDA), oxidative stress index (OSI), tumor necrosis factor-alpha (TNF-α), and 8-hydroxy-2’ deoxyguanosine (8-OHdG), were significantly elevated (P<0.05). Conversely, superoxide dismutase (SOD) activity and total antioxidant status (TAS) levels were notably decreased (P<0.05). CAST administration significantly attenuated tissue damage by reducing oxidative stress and inflammatory markers while enhancing antioxidant defense (P<0.05). Conclusion: CAST demonstrated a therapeutic effect against ovarian and lung tissue damage induced by T/D, suggesting that it may serve as a potential therapeutic agent for treating ovarian T/D-related injuries. These findings underscore the potential of CAST in clinical settings, particularly as a novel intervention to mitigate complications associated with I/R injuries in gynecological emergencies.