Akademik Veri Yönetim Sistemi
3. International Conference on Agriculture, Food, Veterinary and Pharmacy Sciences (ICAFOP 2019/Trabzon), Trabzon, Türkiye, 16 - 18 Nisan 2019
Abstract
Helichrysum
plicatum subsp. plicatum (Asteraceae)
is known as “ölmez çiçek, altın otu” in Turkey. The capitulums of the plant are
rich from flavonoids and have high antioxidant activity. Alzheimer's disease is a nervous system
disorder in which the brain's sensory functions deteriorate and symptoms such
as forgetfulness, non-speech can be seen. There was cholinergic loss in the
brain in Alzheimer's patients. It has been determined that the amount of acetylcholine
released from cholinergic junctions and synapses decreases. Thus, the treatment
of the disease has been tried by increasing the amount of acetylcholine by
inhibiting acetylcholinesterase enzyme which breaks down acetylcholine by
hydrolysis. In this study four different extracts were fractionated from Helichrysum plicatum subsp. plicatum (Asteraceae).
Acetylcholinesterase and butyrylcholinesterase inhibitory activities of n-hexane,
water, dichloromethane, ethyl acetate extract in 100 μg / mL were compared with
commercial Donepezil. While The value of acetylcholinesterase inhibition of the
ethyl acetate extract is %18±3, the other extracts have not significant
cholinesterase inhibition activity.
Keywords: Helichrysum plicatum subsp. plicatum,
acetylcholinesterase, butyrylcholinesterase, Alzheimer