Akademik Veri Yönetim Sistemi
31. ULUSAL BİYOKİMYA KONGRESİ 2020, Ankara, Türkiye, 18 - 20 Aralık 2020, cilt.45, ss.36
OBJECTIVES: This study aims to investigate the diagnostic value of
ghrelin in acute appendicitis and the correlation between ghrelin and routine
laboratory tests such as white blood cell (WBC), C-reactive protein (CRP).
MATERIALS and METHODS: We prospectively evaluated patients aged 16-
80 years who were operated for acute appendicitis between October 2018 and
December 2018. Blood was preoperatively collected for ghrelin, hemogram,
and CRP assessments. The patients were divided into 3 groups and evaluated
in terms of age, gender, comorbidities, anorexia, ghrelin, leukocyte, CRP,
and body mass index (BMI). The blood taken into the biochemistry tube
for the ghrelin hormone was preserved at –80 degrees after centrifugation.
Measurements were made after the frozen serum samples were dissolved. Human
Ghrelin ELISA Kit Catalog No: E-EL-H1919 96T was used to study serum
samples in the Biochemistry laboratory in accordance with the test procedure.
RESULTS: The study included 30 healthy individuals, 29 patients with noncomplicated appendicitis, and 29 patients with complicated appendicitis. The
groups were not statistically different in terms of age, gender, comorbidities,
BMI, or ghrelin levels (p>0.05). Anorexia and leukocyte and CRP levels
were significantly higher in patients with acute appendicitis (p<0.001).
Ghrelin level and leukocyte count were not significantly correlated.
CONCLUSIONS: Serological tests such as WBC and CRP can be used in
the diagnosis of acute appendicitis and in determining its severity. Ghrelin
levels increased with increasing acute appendicitis severity, but this finding
was not statistically significant. Further studies with larger samples are
needed to better understand how appetite is affected in acute appendicitis.
Keywords: Acute Appendicitis, C-Reactive Protein, Leukocyte, Ghrelin, Loss Of
Appetite