Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress

Jung T. W., Kim H., Park S. Y., Cho W., Oh H., Lee H. J., ...Daha Fazla

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, cilt.45, sa.11, ss.2181-2191, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 11
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s40618-022-01866-8
  • Dergi Adı: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.2181-2191
  • Anahtar Kelimeler: Stachydrine, AMPK, HO-1, Inflammation, ER stress, Insulin resistance, ACTIVATED PROTEIN-KINASE, OXIDATIVE STRESS, HEME OXYGENASE-1, ER STRESS, KAPPA-B, PATHOGENESIS, LIVER, FIBROSIS, PATHWAY, SYSTEM
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective Insulin resistance develops due to skeletal muscle inflammation and endoplasmic reticulum (ER) stress. Stachydrine (STA), extracted from Leonurus heterophyllus, has been shown to suppress proliferation and induce apoptosis in breast cancer cells and exert anti-inflammatory properties in the brain, heart, and liver. However, the roles of STA in insulin signaling in skeletal muscle remain unclear. Herein, we examined the impacts of STA on insulin signaling in skeletal muscle under hyperlipidemic conditions and its related molecular mechanisms.